Department of Radiation Oncology
University of California, Los Angeles
Radiobiological modeling of heterogeneous tumor cell populations
Overwhelming evidence suggests that tumor cells are highly heterogeneous in response to radiotherapy.
Current radiobiological models excluding the heterogeneity face difficulties interpreting certain tumor radioresistance and the effectiveness (and ineffectiveness) of hypofractionated radiotherapy. In the current research, we model the tomors as two subpopulation, each with its own radiosensitivity but can proliferate into each other under set conditions. The model has shown potential to explain the remarkable radioresistance of GBM and the success of SBRT to certain tumors. We are currently using the model to explore optimal spaial and temporal modulation for a given cancer type.